                         SEQUENCE LISTING

<110>  INSERM
 
<120>  Mutant cytochrome P450 2B6 proteins and uses thereof

<130>  BET11P0327

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Val Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Met Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Trp Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


<210>  2
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ile Asn Met Gly Asp Ser His Val Asp Thr Ser Ser Thr Val Ser 
1               5                   10                  15      


Glu Ala Val Ala Glu Glu Val Ser Leu Phe Ser Met Thr Asp Met Ile 
            20                  25                  30          


Leu Phe Ser Leu Ile Val Gly Leu Leu Thr Tyr Trp Phe Leu Phe Arg 
        35                  40                  45              


Lys Lys Lys Glu Glu Val Pro Glu Phe Thr Lys Ile Gln Thr Leu Thr 
    50                  55                  60                  


Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys Met Lys Lys Thr Gly 
65                  70                  75                  80  


Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Glu 
                85                  90                  95      


Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg Tyr Gly Met Arg Gly 
            100                 105                 110         


Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala Asp Leu Ser Ser Leu 
        115                 120                 125             


Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys Met Ala Thr Tyr Gly 
    130                 135                 140                 


Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe Tyr Asp Trp Leu Gln 
145                 150                 155                 160 


Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe Ala Val Phe Gly Leu 
                165                 170                 175     


Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met Gly Lys Tyr Val Asp 
            180                 185                 190         


Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile Phe Glu Leu Gly Leu 
        195                 200                 205             


Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe Ile Thr Trp Arg Glu 
    210                 215                 220                 


Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly Val Glu Ala Thr Gly 
225                 230                 235                 240 


Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val Val His Thr Asp Ile 
                245                 250                 255     


Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly Arg Leu Lys Ser Tyr 
            260                 265                 270         


Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn Pro Phe Leu Ala Ala 
        275                 280                 285             


Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr Glu Arg His Leu Met 
    290                 295                 300                 


His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile Arg Tyr Glu Ser Gly 
305                 310                 315                 320 


Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser Ala Leu Val Asn Gln 
                325                 330                 335     


Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val Val Met Ser Leu Asn 
            340                 345                 350         


Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro Phe Pro Cys Pro Thr 
        355                 360                 365             


Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp Ile Thr Asn Pro Pro 
    370                 375                 380                 


Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr Ala Ser Glu Pro Ser 
385                 390                 395                 400 


Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser Ser Gly Glu Gly Lys 
                405                 410                 415     


Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg Arg His Ile Leu Ala 
            420                 425                 430         


Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro Ile Asp His Leu Cys 
        435                 440                 445             


Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr Ser Ile Ala Ser Ser 
    450                 455                 460                 


Ser Lys Val His Pro Asn Ser Val His Ile Cys Ala Val Val Val Glu 
465                 470                 475                 480 


Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly Val Ala Thr Asn Trp 
                485                 490                 495     


Leu Arg Ala Lys Glu Pro Ala Gly Glu Asn Gly Gly Arg Ala Leu Val 
            500                 505                 510         


Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu Pro Phe Lys Ala Thr 
        515                 520                 525             


Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Ile 
    530                 535                 540                 


Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln Gln Gly Lys Glu Val 
545                 550                 555                 560 


Gly Glu Thr Leu Leu Tyr Tyr Gly Cys Arg Arg Ser Asp Glu Asp Tyr 
                565                 570                 575     


Leu Tyr Arg Glu Glu Leu Ala Gln Phe His Arg Asp Gly Ala Leu Thr 
            580                 585                 590         


Gln Leu Asn Val Ala Phe Ser Arg Glu Gln Ser His Lys Val Tyr Val 
        595                 600                 605             


Gln His Leu Leu Lys Gln Asp Arg Glu His Leu Trp Lys Leu Ile Glu 
    610                 615                 620                 


Gly Gly Ala His Ile Tyr Val Cys Gly Asp Ala Arg Asn Met Ala Arg 
625                 630                 635                 640 


Asp Val Gln Asn Thr Phe Tyr Asp Ile Val Ala Glu Leu Gly Ala Met 
                645                 650                 655     


Glu His Ala Gln Ala Val Asp Tyr Ile Lys Lys Leu Met Thr Lys Gly 
            660                 665                 670         


Arg Tyr Ser Leu Asp Val Trp Ser 
        675                 680 


<210>  3
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein with 5ST linker

<400>  3

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Val Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Met Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Trp Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Ser Ser Ser Ser Ser Thr 
                485                 490                 495     


Ser Met Thr Asp Met Ile Leu Phe Ser Leu Ile Val Gly Leu Leu Thr 
            500                 505                 510         


Tyr Trp Phe Leu Phe Arg Lys Lys Lys Glu Glu Val Pro Glu Phe Thr 
        515                 520                 525             


Lys Ile Gln Thr Leu Thr Ser Ser Val Arg Glu Ser Ser Phe Val Glu 
    530                 535                 540                 


Lys Met Lys Lys Thr Gly Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln 
545                 550                 555                 560 


Thr Gly Thr Ala Glu Glu Phe Ala Asn Arg Leu Ser Lys Asp Ala His 
                565                 570                 575     


Arg Tyr Gly Met Arg Gly Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu 
            580                 585                 590         


Ala Asp Leu Ser Ser Leu Pro Glu Ile Asp Asn Ala Leu Val Val Phe 
        595                 600                 605             


Cys Met Ala Thr Tyr Gly Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp 
    610                 615                 620                 


Phe Tyr Asp Trp Leu Gln Glu Thr Asp Val Asp Leu Ser Gly Val Lys 
625                 630                 635                 640 


Phe Ala Val Phe Gly Leu Gly Asn Lys Thr Tyr Glu His Phe Asn Ala 
                645                 650                 655     


Met Gly Lys Tyr Val Asp Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg 
            660                 665                 670         


Ile Phe Glu Leu Gly Leu Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp 
        675                 680                 685             


Phe Ile Thr Trp Arg Glu Gln Phe Trp Pro Ala Val Cys Glu His Phe 
    690                 695                 700                 


Gly Val Glu Ala Thr Gly Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu 
705                 710                 715                 720 


Val Val His Thr Asp Ile Asp Ala Ala Lys Val Tyr Met Gly Glu Met 
                725                 730                 735     


Gly Arg Leu Lys Ser Tyr Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys 
            740                 745                 750         


Asn Pro Phe Leu Ala Ala Val Thr Thr Asn Arg Lys Leu Asn Gln Gly 
        755                 760                 765             


Thr Glu Arg His Leu Met His Leu Glu Leu Asp Ile Ser Asp Ser Lys 
    770                 775                 780                 


Ile Arg Tyr Glu Ser Gly Asp His Val Ala Val Tyr Pro Ala Asn Asp 
785                 790                 795                 800 


Ser Ala Leu Val Asn Gln Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp 
                805                 810                 815     


Val Val Met Ser Leu Asn Asn Leu Asp Glu Glu Ser Asn Lys Lys His 
            820                 825                 830         


Pro Phe Pro Cys Pro Thr Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu 
        835                 840                 845             


Asp Ile Thr Asn Pro Pro Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln 
    850                 855                 860                 


Tyr Ala Ser Glu Pro Ser Glu Gln Glu Leu Leu Arg Lys Met Ala Ser 
865                 870                 875                 880 


Ser Ser Gly Glu Gly Lys Glu Leu Tyr Leu Ser Trp Val Val Glu Ala 
                885                 890                 895     


Arg Arg His Ile Leu Ala Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro 
            900                 905                 910         


Pro Ile Asp His Leu Cys Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr 
        915                 920                 925             


Tyr Ser Ile Ala Ser Ser Ser Lys Val His Pro Asn Ser Val His Ile 
    930                 935                 940                 


Cys Ala Val Val Val Glu Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys 
945                 950                 955                 960 


Gly Val Ala Thr Asn Trp Leu Arg Ala Lys Glu Pro Ala Gly Glu Asn 
                965                 970                 975     


Gly Gly Arg Ala Leu Val Pro Met Phe Val Arg Lys Ser Gln Phe Arg 
            980                 985                 990         


Leu Pro Phe Lys Ala Thr Thr Pro  Val Ile Met Val Gly  Pro Gly Thr 
        995                 1000                 1005             


Gly Val  Ala Pro Phe Ile Gly  Phe Ile Gln Glu Arg  Ala Trp Leu 
    1010                 1015                 1020             


Arg Gln  Gln Gly Lys Glu Val  Gly Glu Thr Leu Leu  Tyr Tyr Gly 
    1025                 1030                 1035             


Cys Arg  Arg Ser Asp Glu Asp  Tyr Leu Tyr Arg Glu  Glu Leu Ala 
    1040                 1045                 1050             


Gln Phe  His Arg Asp Gly Ala  Leu Thr Gln Leu Asn  Val Ala Phe 
    1055                 1060                 1065             


Ser Arg  Glu Gln Ser His Lys  Val Tyr Val Gln His  Leu Leu Lys 
    1070                 1075                 1080             


Gln Asp  Arg Glu His Leu Trp  Lys Leu Ile Glu Gly  Gly Ala His 
    1085                 1090                 1095             


Ile Tyr  Val Cys Gly Asp Ala  Arg Asn Met Ala Arg  Asp Val Gln 
    1100                 1105                 1110             


Asn Thr  Phe Tyr Asp Ile Val  Ala Glu Leu Gly Ala  Met Glu His 
    1115                 1120                 1125             


Ala Gln  Ala Val Asp Tyr Ile  Lys Lys Leu Met Thr  Lys Gly Arg 
    1130                 1135                 1140             


Tyr Ser  Leu Asp Val 
    1145             


<210>  4
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


